I may be stepping out of bounds here, but I believe that Manifold is currently wedded to Microsoft and .NET. It is unclear to me that if these were used as a virtual server that getting the CUDA drivers working in the VM for running Windows, that Manifold, 1. could take advantage of the underlying hardware and 2. that it would/might break the license agreement for Manifold. Perhaps Dimitri could cover the current state of VM usage for running Manifold.
Just last week I tried to run the Manifold Viewer on a wine installed linux laptop. There were some UI issues, but to my surprise it ran. My hope was to provide a remote client to running an example server on my home desktop.